“Keep on Turkin’”?

Keep on Walking

A s clinicians who evaluate and treat musculoskeletal conditions on a daily basis, we are well aware of the positive effects of regular exercise. Weight control, aerobic fitness, and muscle strength maintenance are all benefits of daily workouts. The cardiovascular system also gains from regular exercise with blood pressure control and high-density lipoprotein (HDL) enhancement, with the commen...

Editorial Keep on Moving

Keep Eyes on Integrins

In mammals, there are 18 kinds of α subunit and 8 kinds of β subunit were discovered, which form 24 combinations (Table 1) [2,3]. Overall, these 24 kinds of integrins can be divided to two groups by containing α-I domain (Table 1 and Figure 1A) or not (Table 1 and Figure 1B). Integrin can regulate its ligand-binding affinity by conformational changes [1]. The adaptor proteins and signal pathway...

B cells keep on editing

proteins fashioned by swollen cardiomyocytes. The mice and their heart muscle cells also had a higher-than-normal death rate. Loss of Notch also spurred more heart stem cells to differentiate. Notch might allow the heart to conserve these cells. The Notch pathway triggers stem cell proliferation in skeletal muscle, and the pathway shortcircuits as we age. The researchers say that it’s possible ...

Keep your eyes on sepsis.

For questions related to this article, contact Sandra Shiramizo at sandralima@ einstein.br. program became necessary as mortality rates for sepsis at the hospital nearly doubled from 2009 to 2010, increasing from 16% to 46%. Some evidence shows that educational programs are associated with improved bundle care and lower hospital mortality rates. This training was essentially an educational prog...